HAP/CaHA

Basic information:

Chemical name: Hydroxyapatite (Calcium Hydroxyphosphate) 

Abbreviation: HAP/CaHA

Molecular Formula: Ca10(PO4)6(OH)2 

CAS No.: 1306-06-5

Purity: ≥95% 

Particle size: 20~45μm (D50 in 25~40μm)

Colour and morphology: white to off-white powder (porous/micropore type) average roundness ≥90%)

Calcium-phosphorus atomic ratio: 1.61≤Ca/P≤1.76

pH range: 6.5~7.5

Total Heavy Metals: ≤50ppm

Bacterial Endotoxin: less than 0.5EU/g

Product Description and Advantages:

Hydroxyapatite is the main inorganic component of human and animal bones. It can be chemically bonded with body tissues at the interface, it has a certain solubility in the body, it can release ions that are harmless to the body, it can participate in the body's metabolism, it has a stimulating or inducing effect on osteogenesis, it can promote the repair of defective tissues, and it shows bioactivity, which is widely used in biomedical fields, and it has been applied in the fields of orthopaedics and dentistry for decades, and its clinical safety has been fully verified.

Hydroxyapatite microspheres can also be used in medical aesthetics, such as dermal fillers and rejuvenation. When injected into the dermis, the microspheres mechanically stimulate the surrounding fibroblasts, and this stimulation activates the signalling pathway within the fibroblasts, which in turn promotes cell proliferation and differentiation, increases collagen synthesis, and achieves progressive improvement, with the advantages of both immediate filler and long-lasting support. Hydroxyapatite has a strong ion exchange capacity and is able to adsorb proteins and growth factors. The porous structure of the microspheres has an even stronger adsorption capacity, resulting in localised autologous growth factor enrichment, further promoting tissue repair and regeneration. The microspheres are able to combine closely with the tissues, not easy to diffuse or shift, low risk of displacement, and can be shaped by massage after injection to fit the facial contour with natural effect.

(1) Advanced nano hydroxyapatite synthesis process can control the micro-size of nano hydroxyapatite and ensure the purity of the final product phase components;

(2) Controlled crystallisation process to ensure uniform pore size and vibration density of the microspheres;

(3) pH neutral, closer to the physiological state of the skin, good material compliance;

(4) Elemental impurities and bacterial endotoxins are far below the safety limit, no allergic reaction;

(5) Advanced ball-making process can ensure good sphericity and appearance.